Those Who Suffer From Orphan Diseases are Orphans No More

Imagine suffering from a debilitating potentially fatal disease so uncommon that it isn’t considered commercially viable to develop a treatment. These are rare or orphan diseases. Amicus Therapeutics is devoted to relieving the suffering of the Rare Disease Community.

 

The diseases that Amicus Therapeutics focuses on are inherited and classified as Lysosomal Storage Diseases. Lysosomes are a group of enzymes whose function it is to break-up large molecules in the cells and disperse the pieces through the cell for recycling. An imperfection in one of those enzymes results in a build up of large molecules ultimately killing the cell.

 

Migalastat is being developed by Amicus Therapeutics as a treatment for Fabry Disease (GCReport). Fabry afflicts 1 out of every 117,000 people. The symptoms of Fabry are manifold: burning and tingling in the hands and feet, skin rash, gastrointestinal, heart, and kidney problems. It can also affect the hearing and mind.

 

Amicus Therapeutics SD-101 is intended to treat Epidermolysis Bullosa. People who suffer from EB experience blistering of the skin that can be caused by types of skin contact others would not think twice about. With Epidermolysis Bullosa the simple act of scratching an itch can cause the skin to blister. In extreme cases, blisters can occur in the mouth and intestines.

 

Pompe Disease is a neuromuscular disorder. Not only does it cause muscle weakness resulting in mobility issues it can also cause the heart to become enlarged. Having Pompe Disease may also lead to respiratory problems. Amicus Therapeutics effort to combat Pompe Disease has been dubbed ATB200/AT2221.

 

The treatments that Amicus Therapeutics is working to develop are known as Chaperone-Advanced Replacement Therapies. Like a chaperone, the drug will in effect show malfunctioning proteins how to act as they should. As the name implies enzyme replacement therapy will replace defective or missing enzymes.

 

Amicus Therapeutics designs their clinical trial by gathering the input of patients, their families, care givers and medical providers. As part of their efforts to relieve the misery of members of the Rare Disease Community Amicus Therapeutics provides patients with guides to help them manage their symptoms.

More about Amicus Therapeutics at http://releasefact.com/2017/08/amicus-therapeutics-funds-its-ground-breaking-new-treatment/

Managing your Osteoarthritis Pain

The Mooresville Tribune recently published an article by Matthew CiRullo called “Understanding and Managing Osteoarthritis” to provide insightful information about this common disease.

 

Arthritis is not actually the disease but rather the expression of general joint disease. However, more than 50 million people in the U.S. suffer from over 100 different variations of the disease (http://www.longislandosteorelief.com/). The disease which causes the soft tissue between joints to be worn away so bone begins to rub against bone is the leading cause of disability in the U.S.

 

Unfortunately, there is no cure for the chronic disease which leads the joints to lose strength and cause pain, though there are many treatments available to help manage the pain.

 

CiRullo suggests there are several options to help self-manage osteoarthritis. Throughout your daily routine, you should move constantly with gentle exercise throughout the day when working or relaxing. This allows the joint to maintain mobility and helps manage the inflammation. Stretching before bed can also help maintain mobility in the joint. When exercising, focus on strengthening the muscles surrounding the joint to relieve stress and pressure.

 

Weight management and quitting smoking are also key to halting osteoarthritis pain. Excess weight puts stress and strain on the joint while smoking creates damage in the connective tissue.

 

If these techniques are not enough to reduce pain, there are several non-invasive medical treatments available. Physical therapy and medications are available to relieve pain, but if these treatments aren’t effective surgery may be required.

 

Luckily, not every osteoarthritis case requires surgery. The Osteo Relief Institute based in New Jersey is dedicated to providing non-surgical treatment for arthritic pain relief.

 

The Osteo Relief Institute has developed a team of certified physical therapists and physicians who are committed to providing effective treatments while avoiding surgery. Many of their treatments use the most advanced technology to treat osteoarthritis with little to no downtime.

 

They are also committed to communicating effectively. The physicians at the Osteo Relief Institute know that medical treatments can seem complicated when it is presented in the difficult medical terms. The Osteoarthritis Relief Institute wants to make sure you understand the treatment path to provide as much information as you need so you can make educated decisions about your treatment.

 

The Osteo Relief Institute provides treatment methods to restore mobility in the joints with arthritis while relieving pain so you can get back to your normal life LinkedIn.

 

Eli Gershkovitch’s Experience in Canadian Craft Beers

Eli is a self-made entrepreneur whose involvement in craft beer has seen him scale the success ladders quite fast. He is a great inspiration to the Millennials particularly because of his impressive academic credentials. Eli Gershkovitch is not only the Steamworks Brewery CEO but also a prominent pilot and lawyer. From his observation, although the youth generation is often scrutinized for their idiosyncratic behavior, they have certainly elicited a golden age for craft beer. Eli Gershkovitch is an aggressive yet calm leader. In fact, you would not easily tell he is a prominent leader by a first glance. The trade master loves freedom, something perceived to have triggered his launching of his brewing sphere.

Factors Depicting How Demand for Craft Beer is Increasing

 

 

According to the market experts, it is expected that by 2020 the craft breweries will be making approximately 20% sales. Consumers are anticipated to purchase the craft beers from the many small wineries. It is very clear that the beer is attracting a broad range of sophisticated personalities. Some of the commonly consumed varieties include the new lagers, India pale ales, coffee stouts, among several others. Canada is among the top countries delivering high-quality beers. In the 2017 contest, Canada scooped 24 medals, 20 of which went to Ontario-based breweries (https://www.crunchbase.com/person/eli-gershkovitch#/entity). The presence of the elemental brew masters like Eli Gershkovitch has also seen the Canadian beer industry grow quite rapidly.

 

 

An Overview of Canada’s Common Beers

 

 

Cameron’s Brewing was among those with competitive choices. One-Eyed Grouse came out as a popular beer and even earned a gold medal for the bitter beer type. Many other Canada-based breweries won assorted medals from various categories like old ale, German Kolsch, brown ale, oatmeal stout, foreign stout, to mention but a few. Steamworks is among the top breweries that are long-standing craft beer in Canada. With Eli Gershkovitch as the CEO, no doubt the factory will continue growing their sale of craft beers (Interview.net). Eli Gershkovitch is appreciated as a brewmaster possessing what it takes to revolutionize the Canadian beer scenes. Eli operates with the guidance of a time-tested motto that guides him in innovating business models steering growth to meet prevailing demands.

 

Who is Glen Wakeman?

Glen Wakeman is the co-founder and CEO of Launchpad Holdings, LLC; a company created in 2015. Launchpad Holdings assists new entrepreneurs via software that helps put together their ideas into an executable plan. Mr. Wakeman got the idea for the venture when contemplating why so many startups fall prey to high failure rates. Eventually discovering a need for structure when it came to basic ideas, and the need for more planning, he found a way to more or less automate the process via software offered in the form of the company’s LaunchPad toolkits. Wakeman began his career at GE Capital and would later become CEO of Doral Financial corporations. Throughout his time and these and other larger corporations, he became regarded as an extraordinary mentor and an entrepreneur. having developed his own formula he regards as 5 key performance areas. Those areas are execution, governance, human capital, leadership and risk management. These principles would go on to be shared through his regular blogging, where he discusses economic strategies and up and coming markets. He also currently assists high-level executives within organizations such as Sitter Bees and Dreamfunded. Over 17,000 employees can attribute their businesses success to Glen Wakeman’s guidance and mentorship. Having an enormous hands on approach, he starts most of his days looking over the numbers from the previous day’s sales and performance. He deals directly with his partners and delegates tasks like revisions and bill payments. He and his team search emerging customer trends and respond to customer inquiries. Graduating with a degree in Economics

Graduating with a degree in Economics and executives within organizations such as Sitter Bees and Dreamfunded. Over 17,000 employees can attribute their businesses success to Glen Wakeman’s guidance and mentorship (CrunchBase). Having an enormous hands on approach, he starts most of his days looking over the numbers from the previous day’s sales and performance. He deals directly with his partners and delegates tasks like revisions and bill payments. He and his team search emerging customer trends and respond to customer inquiries. Graduating with a degree in Economics and Finance from the University of Scranton, following that up with an MBA in finance from the University of Chicago; Wakeman has never been a stranger to working hard, setting and achieving goals. His career is long spanning and continues to prosper.

More at https://ideamensch.com/glen-wakeman/

Equities First Holding, an economic world-class

Not so many companies or organizations around the world have been able to successfully launch a business service product and saw it grow to become a very important aspect used internationally the way Equities First Holdings have done it.Theirs is a success story that immediately took off and gained popularity in the financial sector that saw the company rise and expand to nine different countries in only fifteen years and more information click here.

Now dubbed as one of the leading multinational companies around the world, Equities First Holdings is a proud provider of stock-based loans. The company first opened its doors to its many clients back in 2002 with its innovative business model that had never been applied before.

The unprecedented business service involved them offering credit loans to its customers with them providing collateral for them in form of stocks that were being traded publicly. This became very popular almost immediately with many people who initially lacked other forms of security so as to access loans from other financial institutions and resume it.

This product service is the sole reason that made Equities First Holding to become the alternative choice for people seeking to access any fast working principal capital needed by any of their clients. The customer service that Equities First Holding provided to its clients also proved popular as they ensured that any one that sought their service was fully attended to and served accordingly.

Over the years the company has proved very popular with people who seek fast loans in times of any financial crises. This service is offered to either an individual or business or businesses. Many people that have sought their services have testified of how they were able to solve their financial issues after accessing their loans quite easily. For this reason and much more the company has gained a lot of trust in the financial sector as a bailout option when facing harsh economic times and Equities First Holdings lacrosse camp.

More Visit: https://bloghelpline.com/notable-achievements-equities-first-holdings-llc/

Hair Care Products Tested by Kim Dao

Recently video blogger Kim Dao put ten of the best Japanese hair care products to the test. She tried treatment products, conditioners and shampoos and reviewed all of them. Kim Dao really likes the Venus Spa Hair Fragrance and they are very popular in Japan (https://www.behance.net/kimdao). These spray in products are hair safe perfumes that eliminate odors the hair can collect throughout the day. These are also wonderful at masking other products you may have put in your hair that do not have such an appealing fragrance. Kim Dao also tested out Tsubaki Sheseido extra moist shampoo. This shampoo is packed with natural ingredients and comes in a beautiful coral colored bottle. Tsubaki translates to Camellia flower in Japanese. It gently cleanses and hydrates hair while it enhances elasticity. In addition to the extra moist shampoo, Kim Dao put Tsubaki Sheseido damage care treatment to the test to see if it really does fight the frizzies. This product targets dryness and split ends and is made with Camellia oils. This product can be used as a daily conditioner but it works best as a hair mask that is massaged into the dry and damaged ends of the hair. Let this product set for a bit before rinsing. One of the top rated Japanese hair sprays is by Kao Keep. It comes in a fun purple spray bottle. Kim Dao has been using this product for a few years and it will keep hair very stiff and in place after hair is styled. More of the top ten Japanese products that Kim Dao reviewed can be found here.

Learn more here: https://www.linkedin.com/in/kimdaoblog/

 

Bruno Fagali Provides Expert Legal Advice

Ever since Bruno Fagali first started working as an attorney, he knew what he wanted to do and what he was going to have to make happen to get to the point where he is at right now. Bruno Fagali knows a lot about being an attorney and also knows that he can try different things when he is running his business.

Since Bruno Fagali knows so much about being an Attorney and knows the right way to try different things, he does what he can to help people and has remained committed to the experience.

For him to help people, Bruno Fagali has to make sure that he can show people different things and that they will be able to experience all of the positive parts of being a part of a business. Even when Bruno Fagali was working in different areas, he knew that he could try his best to help all of his clients.

Read more on jusbrasil.com

The Fagali Advocacy organization is something that Bruno Fagali and it helps people realize what the law is supposed to be like. Bruno Fagali is committed to helping people have the best legal experience possible and he has tried his best to show them what they are going to do with their own lives.

When Bruno Fagali first started the organization, he knew that it was going to be something that he would have to work hard at. He also knew that the company would grow when he put the work in to make it happen. For Bruno Fagali, all of this allowed him the chance to grow his practice.

Even when Bruno Fagali is working on the Regulatory or Urban Law, he is doing his best to help people out. He has always had a good idea of what he wants to provide to people and he uses that idea to make his practice the best that it can possibly be. As his legal reach spreads, he is able to show people what they are missing and what they could have if they chose him as their attorney for different legal purposes.

For more information about Bruno Fagali: just click here.

Internal Medicine Through the Hands of Dr. Imran Haque

Based in North Carolina, United States, Dr. Imran Haque is a medical practitioner and a specialist in Internal Medicine. He is an undergraduate of University of North Carolina and honors graduate of medicine from Universidad Iberoamericana (UNIBE), Santo Domingo, and University of Virginia Internal Medicine Roanoke-Salem Program. Dr. Imran is a licensed medical practitioner in North Carolina and owner of Horizon Internal Medicine with a modern facility at Asheboro. He grew as an intern in Maintenance of Certification Program.

An expert in internal medicine field, Dr. Imran diagnoses and offers prescriptions for Epilepsy, Diabetes, Glaucoma, and Pneumonia. In certain instances, some of his patients are referred for additional treatments and diagnostic options when necessary. With over 19 years experience in the field, Dr. Imran Haque has seen his reputation has grown exponentially and is well known for the provision of medical services such as dermal fillers, weight management, Botox, physical examinations, diabetes management, 360 resurfacing for skin revitalization as well as laser hairs.

One of the areas that have really helped residents of North Carolina through Dr. Imran Haque is Venus Body Contouring. This procedure, aimed at enhancing and improving the body shape is popular among residents and non-invasive. It involves the use of heat to awaken natural processes in the body which assist in removing fat. This is through the use of multipolar frequencies alongside electromagnetic field with a pulse to warm the skin enabling the body release stress hormones in hypodermis fat cells. It’s a relatively short procedure with a quick healing process.

A lot of patients come to Dr. Imran Haque for both primary care and in search of a specific treatment for a variety of ailments. One unique aspect that makes him a success is the idea of working with other physicians and specialized doctors to provide professional healthcare and medical information and advice to patients. He is conveniently located in Ramseur, Asheboro and surrounding areas in North Carolina making his practice easily accessible in the state. Reviews from patients previously treated serve as a testimony to Dr. Imran Haque’s professional service delivery in his practice.

https://www.business.com/advice/member/p/imran-haque/

 

https://www.youtube.com/watch?v=a0NzH-nhmmE

Adam Milstein is an Advocate For Jews in an Anti-Semitism Environment

Jewish people are faced with a lot of trials in their lives. For one thing, there are tons of attacks on Jewish as a people. These attacks range from nasty remarks to actual physical attacks on the nation as a whole. Therefore, people need to stick together and support themselves in these trying times. In order to be successful at this, it is important to have a leader who is not only powerful but is also encouraging and unifying. Among the leaders that are reliable is Adam Milstein. Adam Milstein is someone who is more than willing to make sure that people have everything they need to help themselves and others.

 

This current campaign is rather hypocritical by nature. While there is a campaign to include all people whether they are Muslim, Homosexual, Black, Native American or other, there is one group that is excluded from this campaign. This group of people are the Israelis. People who want to be included have to declare their disdain for the Jewish people or else they will be treated like the Jewish people. This is really a trying time for Jewish people in that they are being targeted more than ever by many groups of people.

 

The best thing to do in times like these for a group of people that is under fire is to be on their best behavior. At the same time, they also have to be willing to protect themselves from attacks. This is not going to be an easy time for Jewish people. They need leaders like Adam Milstein more than ever. Fortunately, Adam Milstein has shown a lot of good business sense and the ability to motivate people and spur them to action. With all of the foundations he has set up, he is definitely making an impact in the Jewish community.

https://www.youtube.com/user/AdamMilstein

 

https://ideamensch.com/adam-milstein/